Round: 13
| El Salvador - Reserve league | 2022/01/22 21:00 | Santa Tecla Reserves v Once Deportivo de Ahuachapán - Reserves | L | 3-1 |
| El Salvador - Reserve league | 2021/11/27 17:00 | Once Deportivo de Ahuachapán - Reserves v Santa Tecla Reserves | W | 3-0 |
| El Salvador - Reserve league | 2021/09/25 21:00 | Santa Tecla Reserves v Once Deportivo de Ahuachapán - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2021/04/22 15:30 | Once Deportivo de Ahuachapán - Reserves v Santa Tecla Reserves | D | 2-2 |
| El Salvador - Reserve league | 2021/03/30 20:30 | Santa Tecla Reserves v Once Deportivo de Ahuachapán - Reserves | L | 5-1 |
| El Salvador - Reserve league | 2022/03/05 18:30 | Jocoro FC - Reserves v Once Deportivo de Ahuachapán - Reserves | W | 1-2 |
| El Salvador - Reserve league | 2022/02/27 17:00 | Once Deportivo de Ahuachapán - Reserves v CD Aguila - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2022/02/23 17:00 | Once Deportivo de Ahuachapán - Reserves v Alianza FC San Salvador - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2022/02/20 17:00 | CD Platense Zacatecoluca - Reserves v Once Deportivo de Ahuachapán - Reserves | L | 3-2 |
| El Salvador - Reserve league | 2022/02/13 18:00 | Once Deportivo de Ahuachapán - Reserves v CD Luis Angel Firpo - Reserves | L | 0-1 |
| El Salvador - Reserve league | 2022/02/09 22:00 | AD Chalatenago - Reserves v Once Deportivo de Ahuachapán - Reserves | L | 1-0 |
| El Salvador - Reserve league | 2022/02/06 18:00 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | D | 2-2 |
| El Salvador - Reserve league | 2022/01/29 18:00 | Atletico Marte - Reserves v Once Deportivo de Ahuachapán - Reserves | W | 1-2 |
| El Salvador - Reserve league | 2022/03/13 21:00 | CD Platense Zacatecoluca - Reserves v Santa Tecla Reserves | L | 2-1 |
| El Salvador - Reserve league | 2022/03/05 21:15 | Santa Tecla Reserves v CD Luis Angel Firpo - Reserves | W | 2-0 |
| El Salvador - Reserve league | 2022/02/26 21:00 | AD Chalatenago - Reserves v Santa Tecla Reserves | L | 4-1 |
| El Salvador - Reserve league | 2022/02/23 21:30 | Santa Tecla Reserves v AD Isidro Metapan - Reserves | W | 5-2 |
| El Salvador - Reserve league | 2022/02/19 18:00 | Atletico Marte - Reserves v Santa Tecla Reserves | L | 2-1 |
| El Salvador - Reserve league | 2022/02/12 21:15 | Santa Tecla Reserves v Municipal Limeno - Reserves | L | 1-2 |
| El Salvador - Reserve league | 2022/02/09 22:00 | Santa Tecla Reserves v Alianza FC San Salvador - Reserves | W | 2-0 |
| El Salvador - Reserve league | 2022/02/06 18:00 | CD FAS - Reserves v Santa Tecla Reserves | W | 2-4 |